Radioligand and Expert Systems

Our NIH-supported laboratory has the dual focus of radioligand and expert system development, with a goal of enhancing clinical care. The radioligand component of the laboratory was transferred from the University of Utah to Emory in 1986, and the research focus has continued to be the development of technetium-99m renal tubular radiopharmaceuticals. This focus recently has expanded to include other radioligands, such as one targeting pancreatic cancer. The second focus of the laboratory is to develop a decision support system for the interpretation of radionuclide renal scans. We initially developed specific software for processing MAG3 renal scans (QuantEMTM) to measure the MAG3 clearance and calculate other quantitative parameters important in scan interpretation. Subsequently, we have developed a much more sophisticated version of QuantEM (QuantEM 2.0), which automatically extracts clinically relevant parameters and forwards them to an expert system (RENEX) for analysis. RENEX provides automated scan interpretation for patients referred for suspected renal obstruction and is currently under development. Our mission is radioligand and expert system development to enhance clinical care.

- Andrew T. Taylor, MD
Director, Radioligand and Expert Systems

Faculty

Current Research

Highlights and Accomplishments

NIH Merit Award
Andrew T. Taylor, MD

The prestigious NIH MERIT (Method to Extend Research in Time) Award was initiated to recognize researchers who have demonstrated superior competence and outstanding productivity in their research endeavors. The Award is designed to provide long-term support to investigators with impressive records of scientific achievement in research areas of special importance or promise. Investigators may not apply for a MERIT award but are selected by program staff and/or members of the Advisory Board. Less than 5% of NIH-funded investigators are selected to receive MERIT Awards. Currently, Dr. Taylor is one of 11 investigators with MERIT awards at Emory.

Recent Publications

Lipowska M, Klenc J, Verdes L,Folks RD, Taylor AT. Initial evaluation of 99mTc(CO)3(ASMA) as a renal tracer in healthy human volunteers.  Nucl Med Mol Imaging 2014: in press

Lipowska M, Klenc J, Shetty D, Nye JA, Shim H, Taylor AT.  Al-18F-NODA-butyric acid: Biological evaluation of a new PET renal tracer.  Nucl Med Biol 2014: 41;248-253

Taylor AT.  Radionuclides in Nephrourology:  Part 2:  Pitfalls and diagnostic applications.  J Nucl Med 55:786-798, 2014

Taylor AT.  Radionuclides in Nephrourology:  Part 1: Radiopharmaceuticals, quality control and quantitative indices.  J Nucl Med 2014;55:606-615

Taylor AT: The preoperative evaluation: medical necessity or unnecessary expense.  Surgery 2014:155;575-577

Taylor AT, Garcia EV.  Computer-assisted diagnosis in renal nuclear medicine:  Rationale, methodology and interpretative criteria for diuretic renography.  Semin Nucl Med 2014;44:146-158

Contact Information

Nettie Sutton
Research Administrative Assistant
Research Department of Radiology
Emory University Hospital
1364 Clifton Road
Atlanta, GA 30322
E-mail: nsutton@emory.edu